Efficacy and Safety of Leptin-Replacement Therapy and Possible Mechanisms of Leptin Actions in Patients with Generalized Lipodystrophy

Author:

Ebihara Ken1,Kusakabe Toru1,Hirata Masakazu1,Masuzaki Hiroaki1,Miyanaga Fumiko1,Kobayashi Nozomi1,Tanaka Tomohiro1,Chusho Hideki1,Miyazawa Takashi1,Hayashi Tatsuya1,Hosoda Kiminori1,Ogawa Yoshihiro1,DePaoli Alex M.2,Fukushima Masanori3,Nakao Kazuwa1

Affiliation:

1. Department of Medicine and Clinical Science (K.E., T.K., M.H., H.M., F.M., N.K., T.T., H.C., T.M., T.H., K.H., Y.O., K.N.), Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan

2. Amgen Inc. (A.M.D.), Thousand Oaks, California 91319

3. Department of Clinical Trial Management (M.F.), Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference37 articles.

1. Positional cloning of the mouse obese gene and its human homologue.;Zhang;Nature,1994

2. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action.;Frederich;Nat Med,1995

3. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects.;Maffei;Nat Med,1995

4. Serum immunoreactive-leptin concentrations in normal-weight and obese human.;Considine;N Engl J Med,1996

5. Identification and expression cloning of a leptin receptor, OB-R.;Tartaglia;Cell,1995

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