Obesity and Sex Steroid Changes across Puberty: Evidence for Marked Hyperandrogenemia in Pre- and Early Pubertal Obese Girls

Author:

McCartney Christopher R.12,Blank Susan K.12,Prendergast Kathleen A.12,Chhabra Sandhya12,Eagleson Christine A.12,Helm Kristin D.12,Yoo Richard3,Chang R. Jeffrey3,Foster Carol M.4,Caprio Sonia5,Marshall John C.12

Affiliation:

1. The Center for Research in Reproduction (C.R.M., S.K.B., K.A.P., S.Ch., C.A.E., K.D.H., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908

2. Division of Endocrinology (C.R.M., S.K.B., K.A.P., S.Ch., C.A.E., K.D.H., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908

3. Division of Reproductive Endocrinology and Infertility (R.Y., R.J.C.), Department of Reproductive Medicine, University of California, San Diego, San Diego, California 92103

4. Division of Endocrinology (C.M.F.), Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84108

5. Department of Pediatrics (S.Ca.), Yale University School of Medicine, New Haven, Connecticut 06520

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference31 articles.

1. The insulin-related ovarian regulatory system in health and disease.;Poretsky;Endocr Rev,1999

2. Body fat distribution and steroid hormone concentrations in obese adolescent girls before and after weight reduction.;Wabitsch;J Clin Endocrinol Metab,1995

3. Low levels of sex hormone-binding globulin in obese children.;Dunkel;J Pediatr,1985

4. Increased visceral adipose tissue is associated with increased circulating insulin and decreased sex hormone binding globulin levels in massively obese adolescent girls.;De Simone;J Endocrinol Invest,2001

5. Insulin, androgen, and gonadotropin concentrations, body mass index, and waist to hip ratio in the first years after menarche in girls with regular menstrual cycles, irregular menstrual cycles, or oligomenorrhea.;Hooff;J Clin Endocrinol Metab,2000

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