1. Discovery Research Laboratories I, Pharmaceutical Division, Takeda Chemical Industries Ltd. (Y.H., H.M., Y.T., T.O., C.K., M.F.), Wadai, Tsukuba, Ibaraki 300-4293, Japan;
2. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba (S.U.), Tennodai, Tsukuba, Ibaraki 305-8575, Japan