The Impact of Congenital, Severe, Untreated Growth Hormone (GH) Deficiency on Bone Size and Density in Young Adults: Insights from Genetic GH-Releasing Hormone Receptor Deficiency

Author:

Maheshwari Hiralal G.1,Bouillon Roger2,Nijs Jos2,Oganov Victor S.1,Bakulin Alexej V.1,Baumann Gerhard1

Affiliation:

1. Center for Endocrinology (H.G.M., G.B.), Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, Chicago, Illinois 60611

2. Division of Endocrinology (R.B., J.N.), Catholic University, B3000 Leuven, Belgium; and State Research Center, Institute for Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference44 articles.

1. Growth hormone and bone.;Ohlsson;Endocr Rev,1998

2. Reduced bone mineral content in adult patients with growth hormone deficiency.;Rosen;Acta Endocrinol (Copenh),1993

3. Reduced bone mineral density in patients with adult onset growth hormone deficiency.;Holmes;J Clin Endocrinol Metab,1994

4. Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism.;Colao;J Clin Endocrinol Metab,1999

5. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial.;Baum;Ann Intern Med,1996

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