Suppression of Thyrotropin Receptor Constitutive Activity by a Monoclonal Antibody with Inverse Agonist Activity
Author:
Affiliation:
1. Autoimmune Disease Unit, Cedars-Sinai Research Institute and University of California, Los Angeles, School of Medicine, Los Angeles, California 90048
Publisher
The Endocrine Society
Subject
Endocrinology
Link
http://academic.oup.com/endo/article-pdf/148/5/2375/11060509/endo2375.pdf
Reference53 articles.
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2. The thyrotropin receptor: interaction with thyrotropin and autoantibodies.;Rapoport;Endocr Rev,1998
3. A molecular dissection of the glycoprotein hormone receptors.;Vassart;Trends Biochem Sci,2004
4. In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence.;Van Sande;Eur J Biochem,1995
5. The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.;Zhang;Endocrinology,2000
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