Mechanical Loading Down-Regulates Peroxisome Proliferator-Activated Receptor γ in Bone Marrow Stromal Cells and Favors Osteoblastogenesis at the Expense of Adipogenesis

Author:

David Valentin1,Martin Aline1,Lafage-Proust Marie-Hélène1,Malaval Luc1,Peyroche Sylvie1,Jones David B.2,Vico Laurence1,Guignandon Alain1

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale Unité 890 and Université Jean Monnet (V.D., A.M., M.-H.L.-P., L.M., S.P., L.V., A.G.), F-42023 St-Etienne, France

2. Experimental Orthopedics and Biomechanics (D.B.J.), Philipps University, Baldingerst, D-35033 Marburg, Germany

Publisher

The Endocrine Society

Subject

Endocrinology

Reference52 articles.

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2. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model.;Muraglia;J Cell Sci,2000

3. Osteogenic imprinting upstream of marrow stromal cell differentiation.;Satomura;J Cell Biochem,2000

4. Multilineage potential of adult human mesenchymal stem cells.;Pittenger;Science,1999

5. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies.;Meunier;Clin Orthop Relat Res,1971

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