Melanocortin-4 Receptor Gene: Case-Control Study and Transmission Disequilibrium Test Confirm that Functionally Relevant Mutations Are Compatible with a Major Gene Effect for Extreme Obesity-Reference-Cited by-同舟云学术

Melanocortin-4 Receptor Gene: Case-Control Study and Transmission Disequilibrium Test Confirm that Functionally Relevant Mutations Are Compatible with a Major Gene Effect for Extreme Obesity

Published:2003-09-01 Issue:9 Volume:88 Page:4258-4267
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Hinney Anke¹,Hohmann Sarah²,Geller Frank³,Vogel Constanze¹,Hess Claudia²,Wermter Anne-Kathrin¹,Brokamp Britta¹,Goldschmidt Hanspeter⁴,Siegfried Wolfgang⁵,Remschmidt Helmut¹,Schäfer Helmut³,Gudermann Thomas²,Hebebrand Johannes¹

Affiliation:

1. Clinical Research Group (A.H., C.V., A.-K.W., B.B., H.R., J.H.), Department of Child and Adolescent Psychiatry, Philipps-University of Marburg, D-35039 Marburg, Germany;

2. Department of Pharmacology and Toxicology (S.H., C.H., T.G.), Philipps-University of Marburg, D-35033 Marburg, Germany;

3. Institute of Medical Biometry and Epidemiology (F.G., H.S.), Philipps-University of Marburg, D-35037 Marburg, Germany;

4. Spessart Klinik (H.G.), D-63619 Bad Orb, Germany;

5. Obesity Treatment Centre Insula (W.S.), D-83489 Berchtesgaden, Germany

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Link

http://academic.oup.com/jcem/article-pdf/88/9/4258/13133530/jcem4258.pdf

Reference28 articles.

1. Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin.;Gotoda;Diabetologia,1997