1. Department of Biochemistry and Molecular Biology (Y.N., T.S., M.H., A.I.), School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan;
2. Bio-oriented Technology Research Advancement Institution (M.H.), Minato-ku, Tokyo 105-0001, Japan;
3. Department of Obstetrics and Gynecology (T.H., K.O.), Hiroshima University School of Medicine, Minami-ku, Hiroshima 734-8551, Japan