A Novel in Vivo Rabbit Model of Hypercatabolic Critical Illness Reveals a Biphasic Neuroendocrine Stress Response

Author:

Weekers Frank1,Van Herck Erik2,Coopmans Willy2,Michalaki Marina1,Bowers Cyril Y.3,Veldhuis Johannes D.4,Van den Berghe Greet1

Affiliation:

1. Department of Intensive Care Medicine (F.W., G.V.d.B., M.M.), Catholic University of Leuven, Leuven B-3000, Belgium

2. Burn Unit and Center for Experimental Surgery & Anesthesiology and Laboratory for Experimental Medicine and Endocrinology (E.V.H., W.C.), Catholic University of Leuven, Leuven B-3000, Belgium

3. Department of Medicine (C.Y.B.), Division of Endocrinology, Tulane University Medical Center, New Orleans, Louisiana 70112-2699

4. Department of Medicine (J.D.V.), Division of Endocrinology, University of Virginia Health Sciences Center, Charlottesville, Virginia 29908

Publisher

The Endocrine Society

Subject

Endocrinology

Reference46 articles.

1. Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients.;Streat;J Trauma,1987

2. Increased mortality associated with growth hormone treatment in critically ill adults.;Takala;N Engl J Med,1999

3. The somatotropic axis in critical illness: effect of continuous growth hormone releasing hormone and GH releasing peptide-2 infusion.;Van den Berghe;J Clin Endocrinol Metab,1997

4. Acute and prolonged critical illness as different neuroendocrine paradigms.;Van den Berghe;J Clin Endocrinol Metab,1998

5. Involvement of corticotropin-releasing factor in ether stress inhibition of growth hormone secretion in the rat.;Rivier;Endocrinology,1985

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