Lisofylline, a Novel Antiinflammatory Agent, Protects Pancreatic β-Cells from Proinflammatory Cytokine Damage by Promoting Mitochondrial Metabolism

Author:

Chen Meng1,Yang Zandong1,Wu Runpei1,Nadler Jerry L.1

Affiliation:

1. Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908

Publisher

The Endocrine Society

Subject

Endocrinology

Reference38 articles.

1. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus.;Rabinovitch;Biochem Pharmacol,1998

2. Selective pharmacological inhibition of murine and human IL-12-dependent Th1 differentiation and IL-12 signaling.;Coon;J Immunol,1999

3. Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1β-induced dysfunction in cultured rat islets.;Bleich;Endocrinology,1996

4. Effects of lisofylline on hyperoxia-induced lung injury;George;Am J Physiol,1999

5. β-Cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes.;Wollheim;Diabetologia,2000

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