Irreversible Inhibition of Metabolic Function and Islet Destruction after a 36-Hour Exposure to Interleukin-1β*
Author:
Affiliation:
1. The Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104
Publisher
The Endocrine Society
Subject
Endocrinology
Link
http://academic.oup.com/endo/article-pdf/138/12/5301/10900068/endo5301.pdf
Reference43 articles.
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2. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction.;Rabinovitch;Diabetes Rev,1993
3. Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an L-arginine-dependent nitric oxide generation mechanism.;Southern;FEBS Lett,1990
4. Interleukin-1-induced expression of nitric oxide synthase in insulin-producing cells is preceded by c-fos induction and depends on gene transcription and protein synthesis.;Eizirik;FEBS Lett,1993
5. Tyrosine kinase involvement in IL-1β-induced expression of iNOS by β-cells purified from islets of Langerhans;Corbett;Am J Physiol,1994
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