Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways Are Not Sufficient for Insulin-Like Growth Factor I-Induced Mitogenesis and Tumorigenesis

Author:

Scrimgeour Angus G.1,Blakesley Vicky A.1,Stannard Bethel S.1,LeRoith Derek1

Affiliation:

1. From the Section on Molecular and Cellular Physiology, Diabetes Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892-1770

Publisher

The Endocrine Society

Subject

Endocrinology

Reference45 articles.

1. Tyrosine phosphorylation of common and specific sets of cellular proteins rapidly induced by insulin, insulin-like growth factor I, and epidermal growth factor in an intact cell.;Kadowaki;J Biol Chem,1987

2. Substrates and signaling complexes: the tortured path to insulin action.;Roth;J Biol Chem,1992

3. The mitogen-activated protein kinases, ERK1 and ERK2.;Cobb;Semin Cancer Biol,1994

4. Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.;Williams;Proc Natl Acad Sci USA,1993

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