Expression of Different 17β-Hydroxysteroid Dehydrogenase Types and Their Activities in Human Prostate Cancer Cells*

Author:

Castagnetta Luigi A. M.12,Carruba Giuseppe1,Traina Adele2,Granata Orazia M.2,Markus Monika3,Pavone-Macaluso Michele4,Blomquist Charles H.5,Adamski Jerzy6

Affiliation:

1. Institute of Oncology (L.A.M.C., G.C.), Policlinico, University Medical School

2. Experimental Oncology and Molecular Endocrinology Units, Palermo Branch of the National Cancer Institute of Genoa (L.A.M.C., A.T., O.M.G.), Cancer Hospital Center, Palermo, Italy

3. Max Planck Institute for Experimental Endocrinology (M.M.), Hannover, Germany

4. Institute of Urology (M.P.-M.), Policlinico, University Medical School

5. The Department of Obstetrics and Gynecology, Healthpartners for Environment and Health, St. Paul-Ramsey Medical Center (C.H.B.), St. Paul, Minnesota 55101-2595

6. GSF- National Research Center, Institute of Mammalian Genetics (J.A.), Neuherberg, Germany

Publisher

The Endocrine Society

Subject

Endocrinology

Reference36 articles.

1. 17β-Hydroxysteroid dehydrogenases: isozymes and mutations.;Andersson;J Endocrinol,1995

2. Oestradiol 17β-hydroxysteroid dehydrogenase: its family and function.;Reed;J Endocrinol,1991

3. Complete amino acid sequence of human placental 17β-hydroxysteroid dehydrogenase deduced from cDNA.;Peltoketo;FEBS Lett,1988

4. Characterization of cDNAs for human estradiol 17β-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5′-termini in human placenta.;Luu-The;Mol Endocrinol,1989

5. Expression cloning and characterization of human 17β-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20α-hydroxysteroid dehydrogenase activity.;Wu;J Biol Chem,1993

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