Comparison of 6-s-cis- and 6-s-trans-Locked Analogs of 1α,25-Dihydroxyvitamin D3 Indicates That the 6-s-cis Conformation Is Preferred for Rapid Nongenomic Biological Responses and That Neither 6-s-cis- nor 6-s-trans-Locked Analogs Are Preferred for Genomic Biological Responses

Author:

Norman Anthony W.12,Okamura William H.3,Hammond Marion W.3,Bishop June E.2,Dormanen Murray C.2,Bouillon Roger4,van Baelen Hugo4,Ridall Amy L.5,Daane Elizabeth5,Khoury Ramzi5,Farach-Carson Mary C.152

Affiliation:

1. Division of Biomedical Sciences (A.W.N.), California 92521,

2. Departments of Biochemistry (A.W.N., J.E.B., M.C.D., M.C.F-C.), California 92521,

3. Chemistry (W.H.O., M.W.H.), University of California, Riverside, California 92521,

4. Laboratorium voor Experimentele Geneeskunde en Endocrinologie (R.B., H.v.B.), Katholieke Universiteit Leuven, Leuven B-3000, Belgium,

5. Department of Basic Sciences (A.L.R., E.D., R.K., M.C.F-C.), University of Texas Dental Branch, Houston, Texas 77030

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference58 articles.

1. The role of the vitamin D endocrine system in health and disease.;Reichel;N Engl J Med,1989

2. Structure-function relationships in the vitamin D endocrine system.;Bouillon;Endocr Rev,1995

3. 1α,25 (OH)2 vitamin D3-regulated expression of the eukaryotic genome.;Hannah;Nutr Rev,1994

4. Transcriptional control of vitamin D-regulated proteins.;Lian;J Cell Biochem,1992

5. Vitamin D-mediated gene expression.;Lowe;Crit Rev Eukar Gene Exp,1992

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