Efficacy and Safety of Thermal Ablation for Solitary T1bN0M0 Papillary Thyroid Carcinoma: A Multicenter Study

Author:

Cao Xiao-Jing1ORCID,Liu Juan2,Zhu Ya-Lin3,Qi Lu4,Liu Geng5,Wang Hong-Ling6,Wang Zhong-Hua7,Zhou Ying8,He Jun-Feng9,Guo Jian-Qin10,Shi Li-Li11,Jian Mei12,Shataer Aini6,Yan Guo-Zhen9,Zhao Zhen-Long1,Wei Ying1,Peng Li-Li1,Li Yan1,Che Ying3,Wang Shu-Rong24ORCID,Yu Ming-An1ORCID

Affiliation:

1. Department of Interventional Ultrasound Medicine, China-Japan Friendship Hospital, Beijing, China

2. Department of Thyroid, Beijing Beicheng Chinese Medicine Hospital, Beijing, China

3. Department of Ultrasound, the First Affiliated Hospital of Dalian Medical University, Dalian, China

4. Department of Medical Ultrasound, Yantai Affliated Hospital of Binzhou Medical University, Yantai, China

5. Department of Ultrasound, Wuhai People’s Hospital, Wuhai, China

6. Department of Breast and Thyroid Surgery, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China

7. Special Inspection Section, Wendeng District People’s Hospital, Weihai, China

8. First Department of Surgery, Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang, China

9. Department of Ultrasound, the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou, China

10. Department of Interventional Ultrasound, Qinghai Provincial People’s Hospital, Xining, China

11. Department of Ultrasound, Laixi Municipal Hospital, Laixi, China

12. Department of Ultrasound, Bayannur Hospital, Bayannur, China

Abstract

Abstract Background Ultrasound-guided thermal ablation plays an important role in the management of thyroid disease. The objective of this study was to evaluate the feasibility, efficacy, and safety of thermal ablation for patients with solitary T1bN0M0 papillary thyroid carcinoma (PTC) who are ineligible for or unwilling to undergo surgery. Materials and Methods Data pertaining to 172 patients (38 males and 134 females) who received thermal ablation therapy at 12 hospitals between April 2015 and March 2020 were retrospectively analyzed. The mean duration of follow-up was 24.9 ± 14.1 months (range, 12–60). The technical feasibility, technical success, efficacy, and safety of treatment were analyzed. Postablation tumor size at various time points was compared with preablation measurement. Results All patients selected for thermal ablation received enlarged ablation, according to contrast-enhanced ultrasound postablation. The maximum diameter and volume of ablation zone at 6, 12, 18, 24, 36, and 48 months postablation were significantly smaller than those recorded preablation (P < 0.05 for all). At the most recent follow-up, 106 (61.6%) tumors had completely disappeared. The rate of lymph node metastasis was 0.6% (1/172) and the incidence of new tumors was 1.2% (2/172). The overall complication rate was 5.2% (9/172) (major complications: 4.6% [8/172]; minor complications: 0.6% [1/172]). All major complications were relieved within 4 months postablation. Conclusion Thermal ablation may be a feasible, effective, and safe treatment option for patients with solitary T1bN0M0 PTC who are ineligible for or unwilling to undergo surgery. It may provide a novel treatment option for selected patients.

Funder

Natural Science Foundation of Shandong Province

Beijing Municipal Science & Technology Commission

Joint Found Project of Biomedical Transformation Engineering Research Center

Beijing Chemical Technology University and China-Japan Friendship Hospital

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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