The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study-Reference-Cited by-同舟云学术

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

Published:2024-04-30 Issue:9 Volume:109 Page:e1697-e1707
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Eriksen Rebeca¹,White Margaret C²,Dawed Adem Y²,Perez Isabel Garcia¹,Posma Joram M³⁴,Haid Mark⁵,Sharma Sapna⁶⁷,Prehn Cornelia⁵^ORCID,Thomas E Louise⁸,Koivula Robert W⁹¹⁰,Bizzotto Roberto¹¹^ORCID,Mari Andrea¹¹,Giordano Giuseppe N⁹,Pavo Imre¹²,Schwenk Jochen M¹³,De Masi Federico¹⁴,Tsirigos Konstantinos D¹⁴,Brunak Søren¹⁴¹⁵^ORCID,Viñuela Ana¹⁶,Mahajan Anubha¹⁷,McDonald Timothy J¹⁸,Kokkola Tarja¹⁹,Rutters Femke²⁰,Beulens Joline²⁰,Muilwijk Mirthe²⁰,Blom Marieke²⁰,Elders Petra²⁰,Hansen Tue H²¹,Fernandez-Tajes Juan¹⁷,Jones Angus¹⁸,Jennison Chris²²,Walker Mark²³,McCarthy Mark I¹⁰¹⁷²⁴,Pedersen Oluf²¹^ORCID,Ruetten Hartmut²⁵,Forgie Ian²,Holst Jens J²¹²⁶,Thomsen Henrik S²⁷,Ridderstråle Martin²⁸,Bell Jimmy D⁸,Adamski Jerzy⁵²⁹³⁰,Franks Paul W⁹³¹,Hansen Torben²¹^ORCID,Holmes Elaine¹,Frost Gary¹^ORCID,Pearson Ewan R²^ORCID

Affiliation:

1. Section for Nutrition Research, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London , London SW7 2AZ , UK

2. Population Health & Genomics, School of Medicine, University of Dundee , Dundee DD1 9SY , UK

3. Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London , London SW7 2AZ , UK

4. Health Data Research UK , London NW1 2BE , UK

5. Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH) , D-85764 Neuherberg , Germany

6. German Center for Diabetes Research , 85764 Neuherberg , Germany

7. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health , Neuherberg, 85764 Bavaria , Germany

8. Research Centre for Optimal Health, School of Life Sciences, University of Westminster , London W1W 6UW , UK

9. Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Skåne University Hospital , 221 00 Malmö , Sweden

10. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford , Oxford OX3 7LE , UK

11. Institute of Neuroscience–National Research Council , 35127 Padua , Italy

12. Eli Lilly Regional Operations GmbH , 1030 Vienna , Austria

13. Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH—Royal Institute of Technology , SE-100 44 Stockholm , Sweden

14. Department of Health Technology, Kgs Lyngby and The Novo Nordisk Foundation Center for Protein Research, Technical University of Denmark, University of Copenhagen , 2200 Copenhagen , Denmark

15. Novo Nordisk Foundation Center for Protein Research, University of Copenhagen , DK-2200 Copenhagen , Denmark

16. Biosciences Institute, Newcastle University , Newcastle upon Tyne NE2 4HH , UK

17. Wellcome Centre for Human Genetics, University of Oxford , Oxford OX3 7BN , UK

18. NIHR Exeter Clinical Research Facility, Royal Devon & Exeter Hospital , Exeter EX2 5DW , UK

19. Department of Medicine, University of Eastern Finland and Kuopio University Hospital , FI-70211 Kuopio , Finland

20. Department of Epidemiology and data Science, Amsterdam Public Health Institute, Amsterdam UMC, location VUMC , 1007 Amsterdam , the Netherlands

21. The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen , 2200 Copenhagen , Denmark

22. Department of Mathematical Sciences, University of Bath , Bath BA2 7AY , UK

23. Institute of Cellular Medicine (Diabetes), Newcastle University , Newcastle upon Tyne NE3 1DQ , UK

24. NIHR Oxford Biomedical Research Centre, Churchill Hospital , Oxford OX3 7LH , UK

25. Sanofi-Aventis Deutschland GmbH, R&D , 65926 Frankfurt am Main , Germany

26. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , 2200 Copenhagen , Denmark

27. Faculty of Medical and Health Sciences, University of Copenhagen , 2200 Copenhagen , Denmark

28. Novo Nordisk Fonden Tuborg Havnevej 19 , 2900 Hellerup , Denmark

29. Lehrstuhl für Experimentelle Genetik, Technische Universität München , 85350 Freising-Weihenstephan , Germany

30. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore , Singapore 117597 , Singapore

31. Department of Nutrition, Harvard School of Public Health , Boston, MA 02115 , USA

Abstract

Abstract Context The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes. Conclusion These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.

Funder

Innovative Medicines Initiative

European Union

Imperial College

NIHR

Wellcome Investigator

NIHR Senior Investigator

STAR

Swedish Research Council

Lund University Diabetes Centre

Strategic Research Area Exodiab

Swedish Foundation for Strategic Research