DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances

Author:

Ballesteros Mónica123ORCID,Gil-Lluís Pilar4,Ejarque Miriam35,Diaz-Perdigones Cristina35,Martinez-Guasch Laia135,Fernández-Veledo Sonia35,Vendrell Joan135ORCID,Megía Ana135ORCID

Affiliation:

1. Department of Medicine and Surgery, Rovira i Virgili University , Tarragona , Spain

2. Department of Obstetrics and Gynecology. University Hospital of Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili (IISPV) , Tarragona , Spain

3. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)-Instituto de Salud Carlos III , Madrid , Spain

4. Department of Endocrinology and Nutrition, University Hospital of Tortosa Verge de la Cinta , Tarragona , Spain

5. Department of Endocrinology and Nutrition. Research Unit. University Hospital of Tarragona Joan XXIII-Institut d´Investigació Sanitària Pere Virgili (IISPV) , Tarragona , Spain

Abstract

Abstract Context DNA methylation in the diagnosis of gestational diabetes. Objective To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances. Methods Two-stage observational study performed between July 2006 and December 2010, at University Hospital. Forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. The main outcome measures were GDM, type 2 diabetes or prediabetes at 4 years postpartum. Results We identified 3 CpG sites related to LINC00917, TRAPPC9, and LEF1 that were differentially methylated in women with GDM and abnormal glucose tolerance; and sites associated with LINC00917 and TRAPPC9 were independently associated with an abnormal glucose tolerance status 4 years postpartum after controlling for clinical variables. Moreover, the site associated with LINC00917 and the combination of the 3 sites had the highest predictive values. Conclusion Our results suggest that some of these sites may be implicated in the development of GDM and postpartum abnormal glucose tolerance.

Funder

Associació Catalana de Diabetis

Spanish Ministry of Economy and Competitiveness

Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders

Instituto de Salud Carlos III

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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