1. Department of Medical Biotechnology & Translational Medicine, University of Milan , 20095 Milan , Italy
2. Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne NE1 4LP , UK
3. Translational & Clinical Research Institute, University of Newcastle-upon-Tyne , Newcastle upon Tyne NE1 4LP , UK