Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years

Author:

Mitchell Adam1ORCID,Fall Tove2,Melhus Håkan3ORCID,Lind Lars4ORCID,Michaëlsson Karl1ORCID,Byberg Liisa1ORCID

Affiliation:

1. Department of Surgical Sciences, Medical Epidemiology, Uppsala University, 751 85 Uppsala, Sweden

2. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden

3. Department of Medical Sciences, Clinical Pharmacogenomics and Osteoporosis, Uppsala University, 751 85 Uppsala, Sweden

4. Department of Medical Sciences, Clinical Epidemiology, Uppsala University, 751 85 Uppsala, Sweden

Abstract

Abstract Context In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip. Objective This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone area and BMD. Methods In 3 cohorts, the Swedish Mammography Cohort Clinical (SMCC; n = 1060), Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 483), and Uppsala Longitudinal Study of Adult Men (ULSAM; n = 203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA) measurements of total hip bone area and BMD on average 8 years apart, a linear regression model was used to assess the effect of T2DM status on change in bone area and BMD at the total hip. Results After meta-analysis, the change in bone area at the total hip was 0.5% lower among those with incident T2DM compared to those without T2DM (–0.18 cm2; 95% CI, –0.30 to –0.06). The change in bone area was similar among those with prevalent T2DM compared to those without (0.00 cm2; 95% CI, –0.13 to 0.13). For BMD, the combined estimate was 0.004 g/cm2 (95% CI, –0.006 to 0.014) among those with incident T2DM and 0.010 g/cm2 (95% CI, –0.000 to 0.020) among those with prevalent T2DM, compared to those without T2DM. Conclusion Those with incident T2DM have a lower expansion in bone area at the total hip compared to those without T2DM.

Funder

Swedish Research Council

Uppsala Multidisciplinary Center for Advanced Computational Science

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

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