Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study-Reference-Cited by-同舟云学术

Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study

Published:2024-06-18 Issue: Volume: Page:
ISSN:0021-972X
Container-title:The Journal of Clinical Endocrinology & Metabolism
language:en
Short-container-title:

Author:

Suturina Larisa¹^ORCID,Lizneva Daria²^ORCID,Lazareva Ludmila¹,Danusevich Irina¹,Nadeliaeva Iana¹,Belenkaya Lilia¹,Atalyan Alina¹,Belskikh Alexey¹,Bairova Tatyana¹,Sholokhov Leonid¹,Rashidova Maria¹,Krusko Olga¹,Darzhaev Zorikto¹,Rinchindorzhieva Marina³,Malanova Ayuna³,Alekseeva Lilia⁴,Sharifulin Eldar¹,Kuzmin Mikhail¹,Igumnov Ilia¹,Babaeva Natalia¹,Tyumentseva Daria¹,Grebenkina Ludmila¹,Kurashova Nadezhda¹,Darenskaya Marina¹,Belyaeva Elena¹,Belkova Natalia¹,Egorova Irina¹,Salimova Madinabonu¹,Damdinova Ludmila¹,Sambyalova Alexandra¹,Radnaeva Elena¹,Dyachenko Olesya¹,Antsupova Karina¹,Trofimova Tatyana¹,Khomyakova Anastasia¹,Ievleva Kseniia¹,Stanczyk Frank Z⁵,Legro Richard S⁶,Yildiz Bulent O⁷,Azziz Ricardo⁸⁹^ORCID

Affiliation:

1. Department of Reproductive Health Protection, Scientific Center for Family Health and Human Reproduction Problems , Irkutsk, 664003 , Russian Federation

2. Reproductive Biology Group, Center for Translational Medicine and Pharmacology, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , USA

3. Republican Perinatal Center of the Ministry of Health of Republic of Buryatia , Ulan-Ude, 670047, Republic of Buryatia , Russian Federation

4. Institute of Medicine, Banzarov Buryat State University , Ulan-Ude, 670000, Republic of Buryatia , Russian Federation

5. Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 , USA

6. Penn State College of Medicine, Penn State University , Hershey, PA 17033 , USA

7. Division of Endocrinology and Metabolism, Hacettepe University School of Medicine, Hacettepe , Ankara, 06100 , Turkey

8. Heersink School of Medicine and School of Public Health, University of Alabama at Birmingham , Birmingham, AL 35249-7333 , USA

9. School of Public Health, University at Albany, SUNY , Rensselaer, NY 12144 , USA

Abstract

Abstract Context Previous studies have shown that the prevalence of polycystic ovary syndrome (PCOS) may vary according to race/ethnicity, although a few studies have assessed women of different ethnicities who live in similar geographic and socioeconomic conditions. Objective To determine the prevalence of PCOS in an unselected multiethnic population of premenopausal women. Design A multicenter prospective cross-sectional study. Settings The main regional employers of Irkutsk Region and the Buryat Republic, Russia. Participants During 2016-2019, 1398 premenopausal women underwent a history and physical exam, pelvic ultrasound, and testing during a mandatory annual employment-related health assessment. Main Outcome Measures PCOS prevalence, overall and by ethnicity in a large medically unbiased population, including Caucasian (White), Mongolic or Asian (Buryat), and mixed ethnicity individuals living in similar geographic and socioeconomic conditions for centuries. Results PCOS was diagnosed in 165/1134 (14.5%) women who had a complete evaluation for PCOS. Based on the probabilities for PCOS by clinical presentation observed in the cohort of women who had a complete evaluation, we also estimated the weight-adjusted prevalence of PCOS in 264 women with an incomplete evaluation: 46.2 or 17.5%. Consequently, the total prevalence of PCOS in the population was 15.1%, higher among Caucasians and women of mixed ethnicity compared to Asians (16.0% and 21.8% vs 10.8%, Pz < .05). Conclusion We observed a 15.1% prevalence of PCOS in our medically unbiased population of premenopausal women. In this population of Siberian premenopausal women of Caucasian, Asian, and mixed ethnicity living in similar geographic and socioeconomic conditions, the prevalence was higher in Caucasian or mixed than Asian women. These data highlight the need to assess carefully ethnic-dependent differences in the frequency and clinical manifestation of PCOS.

Funder

Ministry of Science and Higher Education of the Russian Federation

Publisher

The Endocrine Society

Link

https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae424/58721408/dgae424.pdf

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1. Correction to: “Ethnicity and the Prevalence of Polycystic Ovary Syndrome: The Eastern Siberia PCOS Epidemiology and Phenotype Study”;The Journal of Clinical Endocrinology & Metabolism;2024-08-02

2. The Race for Diagnosis of Polycystic Ovary Syndrome;The Journal of Clinical Endocrinology & Metabolism;2024-07-26