Pharmacologic Weight Management in the Era of Adolescent Obesity

Author:

Raman Vandana1,Gupta Anshu2,Ashraf Ambika P3,Breidbart Emily4,Gourgari Evgenia5,Kamboj Manmohan6,Kohn Brenda4ORCID,Krishnan Sowmya7,Lahoti Amit8,Matlock Kristal9,Mehta Shilpa10,Mistry Sejal11ORCID,Miller Ryan12,Page Laura13,Reynolds Danielle14,Han Joan C15ORCID

Affiliation:

1. Department of Pediatrics, University of Utah , Salt Lake City, Utah 84113 , USA

2. Department of Pediatrics, Children’s Hospital of Richmond at Virginia Commonwealth University , Richmond, Virginia 23219 , USA

3. Division of Pediatric Endocrinology & Diabetes, University of Alabama at Birmingham , Birmingham, Alabama, 35233 , USA

4. Department of Pediatrics, Division Pediatric Endocrinology and Diabetes, NYU Grossman School of Medicine , New York, New York 10016 , USA

5. Department of Pediatrics, Division of Pediatric Endocrinology, Georgetown University , Washington, District of Columbia 20007 , USA

6. Division of Pediatric Endocrinology, Nationwide Children’s Hospital at The Ohio State University , Columbus, Ohio 43205 , USA

7. Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma 73104 , USA

8. Department of Pediatrics, University of Tennessee Health Sciences Center, Le Bonheur Children’s Hospital , Memphis, Tennessee 38163 , USA

9. Department of Pediatrics, Division of Pediatric Endocrinology, Medical University of South Carolina , Charleston, South Carolina 29425 , USA

10. Department of Pediatrics, Division of Pediatric Endocrinology, New York Medical College , Valhalla, New York 10595 , USA

11. Department of Biomedical Informatics, University of Utah , Salt Lake City, Utah 84108 , USA

12. Department of Pediatrics, University of Maryland School of Medicine , Baltimore, Maryland 21093 , USA

13. Department of Pediatrics, Division of Endocrinology, Department of Pediatrics, Duke University , Durham, North Carolina 27710 , USA

14. Diabetes and Endocrinology Center, University of South Florida , Tampa, Florida 33620 , USA

15. Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Icahn School of Medicine at Mount Sinai , New York, New York 10029 , USA

Abstract

Abstract Context Pediatric obesity is a serious health problem in the United States. While lifestyle modification therapy with dietary changes and increased physical activity are integral for the prevention and treatment of mild to moderate obesity in youth, only a modest effect on sustained weight reduction is observed in children and young adults with severe obesity. This underscores the need for additional evidence-based interventions for children and adolescents with severe obesity, including pharmacotherapy, before considering invasive procedures such as bariatric surgery. Evidence Acquisition This publication focuses on recent advances in pharmacotherapy of obesity with an emphasis on medications approved for common and rarer monogenic forms of pediatric obesity. Evidence Synthesis We review medications currently available in the United States, both those approved for weight reduction in children and “off-label” medications that have a broad safety margin. Conclusion It is intended that this review will provide guidance for practicing clinicians and will encourage future exploration for successful pharmacotherapy and other interventions for obesity in youth.

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference96 articles.

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