Co-existing Neuropeptide FF and Gonadotropin-Releasing Hormone 3 Coordinately Modulate Male Sexual Behavior

Author:

Umatani Chie1ORCID,Yoshida Nagisa1,Yamamoto Eri1,Akazome Yasuhisa2,Mori Yasutaka1,Kanda Shinji3,Okubo Kataaki4,Oka Yoshitaka1ORCID

Affiliation:

1. Department of Biological Sciences, Graduate School of Science, the University of Tokyo, Tokyo, Japan

2. Department of Anatomy, St. Marianna University School of Medicine, Kanagawa, Japan

3. Laboratory of Physiology, Atmosphere and Ocean Research Institute, the University of Tokyo, Chiba, Japan

4. Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

Abstract

Abstract Animals properly perform sexual behaviors by using multiple sensory cues. However, neural mechanisms integrating multiple sensory cues and regulating motivation for sexual behaviors remain unclear. Here, we focused on peptidergic neurons, terminal nerve gonadotropin-releasing hormone (TN-GnRH) neurons, which receive inputs from various sensory systems and co-express neuropeptide FF (NPFF) in addition to GnRH. Our behavioral analyses using knockout medaka of GnRH (gnrh3) and/or NPFF (npff) demonstrated that some sexual behavioral repertoires were delayed, not disrupted, in gnrh3 and npff single knockout males, while the double knockout appeared to alleviate the significant defects that were observed in single knockouts. We also found anatomical evidence to show that both neuropeptides modulate the sexual behavior-controlling brain areas. Furthermore, we demonstrated that NPFF activates neurons in the preoptic area via indirect pathway, which is considered to induce the increase in motivation for male sexual behaviors. Considering these results, we propose a novel mechanism by which co-existing peptides of the TN-GnRH neurons, NPFF, and GnRH3 coordinately modulate certain neuronal circuit for the control of behavioral motivation. Our results may go a long way toward understanding the functional significance of peptidergic neuromodulation in response to sensory information from the external environments.

Funder

Japan Society for the Promotion of Science

Publisher

The Endocrine Society

Subject

Endocrinology

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