Distinct Lipids Profiles and Associations With Clinical Indicators and Gut Microbiota in Children With Prader

Distinct Lipids Profiles and Associations With Clinical Indicators and Gut Microbiota in Children With Prader–Willi Syndrome

Published:2023-05-26 Issue:7 Volume:164 Page:
ISSN:1945-7170
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Hou Yaping¹²,Deng Fuli³,Guo Jia³,Lv Lijuan¹²,Ouyang Haimei⁴,Wang Xingwang¹²,Luo Yasha⁵,Chen Xiuwen⁶,Wang Fanghua³^ORCID

Affiliation:

1. Medical Genetic Centre, Guangdong Women and Children’s Hospital , Guangzhou 511400, GD , China

2. Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children’s Hospital , Guangzhou 511400, GD , China

3. School of Food Science and Engineering, South China University of Technology , Guangzhou 510640, GD , China

4. Department of Pediatrics, Guangdong Women and Children’s Hospital , Guangzhou 511400, GD , China

5. Clinical Laboratory Centre, Guangdong Women and Children Hospital , Guangzhou 511400, GD , China

6. Surgery Department, Guangdong Women and Children’s Hospital , Guangzhou 511400, GD , China

Abstract

AbstractLipid metabolism is closely linked to adiposity. Prader–Willi syndrome (PWS) is a typical genetic disorder causing obesity; however, the distinct lipidomic profiles in PWS children have not been thoroughly investigated. Herein, serum lipidomics analyses were simultaneously explored in PWS, simple obesity (SO), and normal children (Normal). Results indicated that the total concentration of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) in the PWS group were significantly deceased compared with both the SO and the Normal group. In contrast, compared with the Normal group, there was an overall significant increase in triacylglycerol (TAG) levels in both the PWS and the SO groups, with the highest found in SO group. Thirty-nine and 50 differential lipid species were screened among 3 groups: between obesity (PWS and SO) and the Normal group. Correlation analysis revealed distinct profiles in PWS that was different from other 2 groups. Notably, PC (P16:0/18:1), PE (P18:0-20:3), PE (P18:0-20:4)) showed significant negative correlation with body mass index (BMI) only in the PWS group. PE (P16:0-18:2) showed a negative association with BMI and weight in the PWS group, but significant positive correlation in the SO group; no statistically significant association was found in the Normal group. We also found a significant negative correlation between Blautia genus abundance and several significantly changed lipids, including LPC (14:0), LPC (16:0), TAG (C50:2/C51:9), TAG (C52:2/C53:9), TAG (C52:3/C53:10), and TAG (C52:4/C53:11), but no significant correlation in the Normal group and the SO group. Similarly, in the PWS group, the Neisseria genus was significantly negatively associated with acylcarnitine (CAR) (14:1), CAR (18:0), PE (P18:0/20:3), and PE (P18:0/20:4), and extremely positively associated with TAG (C52:2/C53:9); no obvious correlations were observed in the Normal group and the SO group.

Funder

Guangdong Basic and Applied Basic Research Foundation

Guangdong Provincial Science

Guangzhou Basic and Applied Basic Research

Medical Scientific Research Foundation

Publisher

The Endocrine Society

Subject

Endocrinology

Link

https://academic.oup.com/endo/advance-article-pdf/doi/10.1210/endocr/bqad084/50455498/bqad084.pdf

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