Lithium Monotherapy in Graves Thyrotoxicosis

Author:

Larkworthy James1ORCID,Kirresh Omar1ORCID,Chakera Ali1ORCID,Ahmed Fahad1

Affiliation:

1. Department of Endocrinology & Diabetes, University Hospitals Sussex NHS Foundation Trust , Brighton, BN2 5BE , UK

Abstract

Abstract Lithium is not commonly used to treat thyrotoxicosis, and there are few reports in the literature of its use as initial therapy in thyrotoxicosis. We describe the case of a patient with Graves thyrotoxicosis and ophthalmopathy, on a background of autoimmune neutropenia, treated successfully with relatively long-term lithium monotherapy. Lithium was used at a lower dose and longer duration than previously reported on, to good effect. We demonstrate that lithium is an important and useful option for those who are unable to tolerate thionamide therapy.

Publisher

The Endocrine Society

Reference10 articles.

1. Diagnosis and management of thyrotoxicosis;Vaidya;BMJ,2014

2. Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK;Pearce;Clin Endocrinol (Oxf),2004

3. Studies on the mechanism of inhibition of thyroid function by lithium;Bagchi;Biochim Biophys Acta,1978

4. Lithium carbonate in the treatment of thyrotoxicosis. A controlled trial;Kristensen;Lancet,1976

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