Secondary Hirata Syndrome in a Neonate: Practical Approach and Management

Author:

Perri Alessandro1ORCID,Fattore Simona1ORCID,Sbordone Annamaria1,Viti Luca2,Pitocco Dario2,Vento Giovanni13

Affiliation:

1. Department of Woman and Child Health Sciences, Child Health Area, University Hospital Agostino Gemelli, Fondazione Policlinico Universitario A. Gemelli IRCCS , 00168 Rome, Lazio , Italy

2. Diabetes Care Unit, Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , 00168 Rome , Italy

3. Department of Woman and Child Health Sciences, Child Health Area, Catholic University of Sacred Heart Seat of Rome , 00168 Rome, Lazio , Italy

Abstract

Abstract Hirata disease, also known as insulin autoimmune syndrome (IAS), is a rare cause of hypoglycemia, due to the presence of insulin autoantibodies (IAA) in the circulating blood. These antibodies are immunoglobulin G (IgG), making placental transfer to the fetus possible. To our knowledge, no reports of IAS have been previously described in the neonatal population. We present a case report of hypoglycemia due to a secondary IAS in a neonate and discuss the management and treatment of the disease.

Publisher

The Endocrine Society

Reference17 articles.

1. Neonatal hypoglycemia;Thompson-Branch;Pediatr Rev,2017

2. Recommendations from the pediatric endocrine society for evaluation and management of persistent hypoglycemia in neonates, infants, and children;Thornton;J Pediatr,2015

3. Postnatal glucose homeostasis in late-preterm and term infants;Committee on Fetus and Newborn;Pediatrics,2011

4. Guidelines for management of neonatal hypoglycemia: are they actually applicable?;Dani;JAMA Pediatr,2020

5. Neonatal hypoglycaemia: a never-ending story?;Vain;Neonatology,2021

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