Neonatal Graves Disease Masquerading as Hemochromatosis

Author:

Maggiotto Liesbeth1ORCID,Mittelman Steven D2,Fallah Roja3ORCID

Affiliation:

1. Division of Neonatology, Department of Pediatrics, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 , USA

2. Division of Pediatric Endocrinology; Department of Pediatrics, UCLA David Geffen School of Medicine , Los Angeles, CA 90095 , USA

3. Riley Hospital for Children, Division of Pediatric Endocrinology & Diabetology; Department of Pediatrics, Indiana University School of Medicine , Indianapolis, IN 46202 , USA

Abstract

Abstract Thyroid autoimmunity is extremely common in the adult population and can affect pregnancy outcomes. Signs in the newborn can range from absent to severe, making the diagnosis easy to miss. We present an interesting case of neonatal Graves disease associated with intrauterine growth restriction, premature delivery, and liver failure with severely high ferritin, thought to be secondary to hemochromatosis. Treatment of the underlying hyperthyroidism caused a rapid resolution of the elevated ferritin and liver failure. This report highlights the importance of considering Graves disease in newborns with liver failure of unknown etiology.

Publisher

The Endocrine Society

Reference9 articles.

1. Thyroid disease in pregnancy;Neale;Clin Perinatol,2007

2. Hyperthyroidism in pregnancy;Cooper;Lancet Diabetes Endocrinol,2013

3. Fetal and neonatal hyperthyroidism and hypothyroidism due to maternal TSH receptor antibodies;Mckenzie;Thyroid,1992

4. Neonatal thyrotoxicosis;Ogilvy-Stuart;Neoreviews,2017

5. Neonatal acute liver failure;Taylor;Liver Transplant,2016

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