The Role of Imatinib in Pediatric Type 1 Diabetes-Reference-Cited by-同舟云学术

The Role of Imatinib in Pediatric Type 1 Diabetes

Published:2024-04-23 Issue:5 Volume:2 Page:
ISSN:2755-1520
Container-title:JCEM Case Reports
language:en
Short-container-title:

Author:

Lavelle Kristen¹²³^ORCID,Chamberlain Chester²³,German Michael¹²³,Anderson Mark¹³,Nip Angel⁴,Gitelman Stephen E³⁴^ORCID

Affiliation:

1. Department of Medicine, Division of Endocrinology and Metabolism, University of California , San Francisco, CA 94143 , USA

2. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California , San Francisco, CA 94143 , USA

3. Diabetes Center, University of California , San Francisco, CA 94143 , USA

4. Department of Pediatrics, Division of Endocrinology, University of California , San Francisco, CA 94143 , USA

Abstract

Abstract We report the first case of imatinib use in an adolescent with diabetes and suggest that it impacts the natural course of disease. A 14-year-old male patient presented in diabetic ketoacidosis (DKA) and was diagnosed with presumed autoantibody-negative type 1 diabetes (T1D) as well as myeloid neoplasm with platelet-derived growth factor receptor beta (PDGFRB) rearrangement. After starting exogenous insulin and imatinib, he experienced a 1.7-point reduction in glycated hemoglobin (HbA1c) and a 71% reduction in insulin requirement with sustained partial diabetes remission. Our case suggests imatinib as a potential therapeutic agent for pediatric T1D.

Funder

NIH

Leona M. and Harry B. Helmsley Charitable Trust

Publisher

The Endocrine Society

Link

https://academic.oup.com/jcemcr/article-pdf/2/5/luae065/57595448/luae065.pdf

Reference25 articles.

1. Amelioration of diabetes by imatinib mesylate (Gleevec): role of beta-cell NF-kappaB activation and anti-apoptotic preconditioning;Hägerkvist;FASEB J,2007

2. Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes;Morita;Cell Metab,2017

3. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice;Louvet;Proc Natl Acad Sci U S A,2008

4. Tyrosine kinase inhibitors and diabetes: a novel treatment paradigm?;Fountas;Trends Endocrinol Metab,2015

5. Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial;Gitelman;Lancet Diabetes Endocrinol,2021