When the Expected Becomes Unexpected: An Acute Presentation of Hypothyroidism

Author:

Martinez Sanchez Andrea1ORCID,Vega Castellvi Claudia1ORCID,Tarkoff Joshua1ORCID,De La Vega Christie1ORCID

Affiliation:

1. Department of Pediatrics, Nicklaus Children's Hospital , Miami, FL 33155 , USA

Abstract

Abstract Myxedema coma is an uncommon and life-threatening manifestation of severe hypothyroidism. Its occurrence in the pediatric population is exceptionally rare and can result from long-standing untreated hypothyroidism or nonadherence to treatment. Identifying this condition can be challenging because it requires a high level of clinical suspicion along with thyroid function testing. We present a 17-year-old female with a history of anxiety who had widespread nonspecific symptoms, including persistent bradycardia, which were found to be caused by hypothyroidism. Our goal is to raise awareness of the varied clinical manifestations of pediatric myxedema to promote early recognition and prompt medical interventions that can lead to better outcomes.

Publisher

The Endocrine Society

Reference19 articles.

1. The myxedema coma in children and adolescents: a rare endocrine emergency—personal experience and review of literature;De Sanctis;Acta Biomed,2021

2. Pediatric myxedema due to autoimmune hypothyroidism: a rare complication of a common disorder;Bonino;Children (Basel),2023

3. Clinical features and outcomes of myxedema coma in patients hospitalized for hypothyroidism: analysis of the United States national inpatient sample;Chen;Thyroid,2024

4. Long-term follow-up and outcomes of autoimmune thyroiditis in childhood;Admoni;Front Endocrinol (Lausanne),2020

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