Influence of Growth Hormone (GH) Receptor Deletion of Exon 3 and Full-Length Isoforms on GH Response and Final Height in Patients with Severe GH Deficiency

Author:

Räz Barbara1,Janner Marco1,Petkovic Vibor1,Lochmatter Didier1,Eblé Andrée1,Dattani Mehul T.2,Hindmarsh Peter C.2,Flück Christa E.1,Mullis Primus E.21

Affiliation:

1. University Children’s Hospital (B.R., M.J., V.P., D.L., A.E., C.E.F., P.E.M.), Pediatric Endocrinology, Diabetology & Metabolism, University Bern, CH-3010 Bern, Switzerland

2. Developmental Endocrinology Research Group (M.T.D., P.C.H., P.E.M.), Clinical and Molecular Genetics Unit, Institute of Child Health, London WC1N 1EH, United Kingdom

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference33 articles.

1. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. The Genentech Growth Study Group.;Blethen;J Clin Endocrinol Metab,1997

2. Derivation and validation of a mathematical model for predicting the response to exogenous recombinant human growth hormone (GH) in prepubertal children with idiopathic GH deficiency. KIGS International Board. Kabi Pharmacia International Growth Study.;Ranke;J Clin Endocrinol Metab,1999

3. The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose.;Ranke;J Clin Endocrinol Metab,2003

4. Prediction of response to growth hormone treatment in short children born small for gestational age: analysis of data from KIGS (Pharmacia International Growth Database).;Ranke,2003

5. A growth prediction model for short children born small for gestational age;Ranke,2002

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