Affiliation:
1. Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093
Abstract
Abstract
Context: In women with polycystic ovary syndrome (PCOS), excess ovarian androgen production is driven by increased LH secretion. Studies conducted in animals suggest that the granulosa cell may influence LH-stimulated theca cell androgen production.
Objective: The objective of this study was to determine whether FSH enhances androgen production in women with PCOS compared with that of normal women.
Design: A prospective study was conducted to compare androgen production in response to FSH in two groups of women.
Setting: The study was conducted in a General Clinical Research Center in a tertiary academic medical center.
Patients: Women with PCOS, 18–35 yr (n = 20), and normal ovulatory controls, 18–35 yr (n = 10), were recruited for study.
Interventions: Serial blood samples were obtained over a 24-h period after an iv injection of recombinant human FSH (150 IU).
Main Outcome Measures: The main outcome measures were serum 17-hydroxyprogesterone (17-OHP), androstenedione (A), dehydroepiandrosterone (DHEA), testosterone (T), and inhibin B (Inh B) responses after FSH administration.
Results: Basal serum 17-OHP, A, and T levels were markedly increased in women with PCOS compared with that observed in normal women. Basal DHEA and Inh B levels were similar to those of normal controls. After FSH injection, PCOS women demonstrated enhanced production of 17-OHP, A, DHEA, and Inh B, whereas in normal women no increases were observed. T levels declined slightly in both groups.
Conclusions: These findings provide evidence that, in PCOS women, theca cell androgen production is enhanced by FSH administration and suggest a granulosa-theca cell paracrine mechanism.
Subject
Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism
Reference43 articles.
1. The polycystic ovary syndrome.;Yen;Clin Endocrinol (Oxf),1980
2. Polycystic ovary syndrome.;Franks;N Engl J Med,1995
3. Polycystic ovary syndrome.;Ehrmann;N Engl J Med,2005
4. Studies of the nature of 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism.;Rosenfield;J Clin Endocrinol Metab,1994
5. Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.;Gilling-Smith;J Clin Endocrinol Metab,1994
Cited by
32 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献