A Novel Tyrosine-Kinase Selective Inhibitor, Sunitinib, Induces Transient Hypothyroidism by Blocking Iodine Uptake

Author:

Mannavola Deborah1,Coco Paola2,Vannucchi Guia1,Bertuelli Rossella2,Carletto Marco3,Casali Paolo G.2,Beck-Peccoz Paolo1,Fugazzola Laura1

Affiliation:

1. Department of Medical Sciences (D.M., G.V., P.B.-P., L.F.), Fondazione Policlinico Istituto di Ricovero e Cura a Carattere Scientifico, 20122 Milan, Italy

2. Department of Oncology (P.Co., R.B., P.Ca.), Istituto Nazionale dei Tumori, 20133 Milan, Italy

3. University of Milan and Endocrine Unit, and Nuclear Medicine Division (M.C.), Fondazione Policlinico Istituto di Ricovero e Cura a Carattere Scientifico, 20122 Milan, Italy

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference15 articles.

1. SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer.;Abrams;Mol Cancer Ther,2003

2. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.;O’Farrell;Clin Cancer Res,2003

3. Activity of SU11248, a multitarget inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.;Motzer;J Clin Oncol,2006

4. New drug increases survival in stomach cancer;Susman;Lancet Oncol,2006

5. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with “standard of care” therapeutic agents for the treatment of breast.;Abrams;Mol Cancer Ther,2003

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