Phosphatidylinositol 3-Kinase/Akt and Ras/Raf-Mitogen-Activated Protein Kinase Pathway Mutations in Anaplastic Thyroid Cancer

Author:

Santarpia Libero1,El-Naggar Adel K.2,Cote Gilbert J.1,Myers Jeffrey N.3,Sherman Steven I.1

Affiliation:

1. Departments of Endocrine Neoplasia and Hormonal Disorders (L.S., G.J.C., S.I.S.), The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009

2. Departments of Pathology (A.K.E.-N.), The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009

3. Departments of Head and Neck Surgery and Cancer Biology (J.N.M.), The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference28 articles.

1. Epidemiology of thyroid cancer;Figge;In: Wartofsky L, ed. Thyroid cancer: a comprehensive guide to clinical management. Totowa, NJ: Humana Press;,1999

2. Anaplastic thyroid cancer.;Pasieka;Curr Opin Oncol,2003

3. BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.;Nikiforova;J Clin Endocrinol Metab,2003

4. Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations.;Quiros;Cancer,2005

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