Abiraterone Acetate to Lower Androgens in Women With Classic 21-Hydroxylase Deficiency

Author:

Auchus Richard J.1,Buschur Elizabeth O.1,Chang Alice Y.2,Hammer Gary D.1,Ramm Carole1,Madrigal David1,Wang George3,Gonzalez Martha3,Xu Xu Steven3,Smit Johan W.4,Jiao James3,Yu Margaret K.5

Affiliation:

1. Division of Metabolism, Diabetes, and Endocrinology (R.J.A., E.O.B., G.D.H., C.R., D.M.), University of Michigan, Ann Arbor, Michigan 48109

2. Division of Endocrinology, Metabolism, Diabetes, and Nutrition (A.Y.C.), Mayo Clinic, Rochester, Minnesota 55905

3. Janssen Research and Development (G.W., M.G., X.S.X., J.J.), Raritan, New Jersey 08869

4. Janssen Research and Development (J.W.S.), 2340 Beerse, Belgium

5. Janssen Research and Development (M.K.Y.), Los Angeles, California 90024

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference38 articles.

1. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency;White;Endocr Rev,2000

2. Congenital adrenal hyperplasia;Speiser;N Engl J Med,2003

3. Evidence for frequent gene conversions in the steroid 21-hydroxylase (P-450c21) gene: implications for steroid 21-hydroxylase deficiency;Higashi;Am J Hum Genet,1988

4. Gene conversion in salt-losing congenital adrenal hyperplasia with absent complement C4B protein;Donohoue;J Clin Endocrinol Metab,1986

5. Gene conversions and rearrangements cause discordance between inheritance of forms of 21-hydroxylase deficiency and HLA types;Morel;J Clin Endocrinol Metab,1989

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