Effect of Odanacatib on BMD and Fractures: Estimates from Bayesian Univariate and Bivariate Meta-analyses

Author:

Gajic-Veljanoski Olga1,Tomlinson George23,Srighanthan Jeevitha1,Adachi Jonathan D.4,Josse Robert35,Brown Jacques P.6,Cheung Angela M.123

Affiliation:

1. Osteoporosis Program (O.G.-V., J.S., A.M.C.), University Health Network/Mt Sinai Hospital, Toronto, ON M5G 2C4, Canada

2. Institute of Health Policy, Management and Evaluation (G.T., A.M.C.), Toronto, ON M5T 3M6, Canada

3. Department of Medicine (G.T., R.J., A.M.C.), University of Toronto, Toronto, ON M5T 3M6, Canada

4. St Joseph's Healthcare and McMaster University (J.D.A.), Hamilton, ON L8N 1Y2, Canada

5. St Michael's Hospital (R.J.), Toronto, ON M5C 2T2, Canada

6. Centre Hospitalier Universitaire de Québec Research Centre and Laval University (J.P.B.), Quebec, QC G1V 4G2, Canada

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference62 articles.

1. Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis;Costa;Nat Rev Rheumatol,2011

2. Papapoulos S , BoneH, DempsterD, et al. Phase 3 fracture trial of odanacatib for osteoporosis–baseline characteristics and study design. J Bone Miner Res. 2012;27(suppl 1). http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid=8dbc5fc5-2225-4249-8504-d02bb8663d10. Accessed December 2, 2013.

3. Merck Co, Inc. A study of MK-0822 in postmenopausal women with osteoporosis to assess fracture risk (MK-0822-018). http://clinicaltrials.gov/ct2/show/NCT00529373?term=NCT00529373&rank=1. Accessed November 27, 2013

4. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density;Bone;J Bone Miner Res,2010

5. Effects of odanacatib on the radius and tibia of postmenopausal women: improvements in bone geometry, microarchitecture and estimated bone strength [published online February 12, 2014];Cheung;J Bone Miner Res

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