Gonadotropin-Releasing Hormone Antagonist Cetrorelix Down-Regulates Proliferating Cell Nuclear Antigen and Epidermal Growth Factor Expression and Up-Regulates Apoptosis in Association with Enhanced Poly(Adenosine 5′-Diphosphate-Ribose) Polymerase Expression in Cultured Human Leiomyoma Cells

Author:

Chen Wei1,Yoshida Shigeki1,Ohara Noriyuki1,Matsuo Hiroya1,Morizane Mayumi1,Maruo Takeshi1

Affiliation:

1. Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, 650-0017, Japan

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference50 articles.

1. Uterine fibroids.;Vollenhoven;Br J Obstet Gynaecol,1990

2. GnRH agonists and uterine leiomyomas.;Broekmans;Hum Reprod,1996

3. The actions of luteinizing hormone-releasing hormone agonists, antagonists, and cytotoxic analogues on the luteinizing hormone-releasing hormone receptors on the pituitary and tumors.;Schally;Infertility Reprod Med Clin North Am,2001

4. Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist.;Kettel;Fertil Steril,1993

5. Treatment of uterine leiomyomas with luteinizing hormone-releasing hormone antagonist Cetrorelix.;Gonzalez-Barcena;Hum Reprod,1997

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