High Prevalence and Possible de Novo Formation of BRAF Mutation in Metastasized Papillary Thyroid Cancer in Lymph Nodes

Author:

Vasko Vasily1,Hu Shuiying2,Wu Guojun3,Xing Jeffrey C.3,Larin Alexandr4,Savchenko Victoria4,Trink Barry3,Xing Mingzhao2

Affiliation:

1. Department of Pediatrics (V.V.), Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814;

2. Division of Endocrinology and Metabolism (S.H., M.X.), Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, Maryland 21287;

3. Department of Otolaryngology (G.W., J.C.X., B.T.), Baltimore, Maryland 21287;

4. Center for Endocrine Surgery (A.L., V.S.), Kiev 25200, Ukraine

Publisher

The Endocrine Society

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference29 articles.

1. Mutations of the BRAF gene in human cancer.;Davies;Nature,2002

2. Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population.;Kim;Yonsei Med J,2004

3. BRAF mutations in metastatic melanoma: a possible association with clinical outcome.;Kumar;Clin Cancer Res,2003

4. The Ras-Raf-MEK-ERK pathway in the treatment of cancer.;Hilger;Onkologie,2002

5. Raf proteins and cancer: B-Raf is identified as a mutational target.;Mercer;Biochim Biophys Acta,2003

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