Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats

Author:

Puche Juan E.12,García-Fernández María2,Muntané Jordi3,Rioja José2,González-Barón Salvador2,Castilla Cortazar Inma12

Affiliation:

1. Department of Medical Physiology (J.E.P., I.C.C.), School of Medicine, University Universidad San Pablo-CEU, 28668 Madrid, Spain

2. Department of Medical Physiology (J.E.P., M.G.-F., J.R., S.G.-B., I.C.C.), School of Medicine, University of Málaga, 29071 Málaga, Spain

3. Department of Internal Medicine (J.M.), Liver Unit, University of Córdoba, 14080 Córdoba, Spain

Publisher

The Endocrine Society

Subject

Endocrinology

Reference42 articles.

1. Insulin-like growth factors and their binding proteins.;Sara;Physiol Rev,1990

2. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.;Veldhuis;J Clin Endocrinol Metab,1995

3. Clinical implications of the reduced activity of the GH-IGF-I axis in older men.;Ceda;J Endocrinol Invest,2005

4. García-Fernández M, Delgado G, Puche JE, González-Barón S, Castilla-Cortázar I 2007 10 January Low doses of insulin-like growth factor I improve insulin resistance, lipid metabolism and oxidative damage in aging rats. Endocrinology [Epub ahead of print]

5. Short stature due to genetic defects affecting growth hormone activity.;Laron;N Engl J Med,1996

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