Pulse Sensitivity of the Luteinizing Hormone β Promoter Is Determined by a Negative Feedback Loop Involving Early Growth Response-1 and Ngfi-A Binding Protein 1 and 2

Author:

Lawson Mark A.1,Tsutsumi Rie2,Zhang Hao2,Talukdar Indrani2,Butler Brian K.1,Santos Sharon J.1,Mellon Pamela L.134,Webster Nicholas J. G.245

Affiliation:

1. Departments of Reproductive Medicine (M.A.L., B.K.B., S.J.S., P.L.M.), San Diego, California 92093;

2. Medicine (R.T., H.Z., I.T., N.J.G.W.), San Diego, California 92093;

3. Neuroscience (P.L.M.,), San Diego, California 92093;

4. University of California San Diego Cancer Center (P.L.M., N.J.G.W.), University of California, San Diego, California 92093;

5. Medical Research Service (N.J.G.W.), Veterans Affairs San Diego Healthcare System, San Diego, California 92161

Publisher

The Endocrine Society

Subject

Endocrinology,Molecular Biology,General Medicine

Reference54 articles.

1. Gonadotropin-releasing hormone and its analogs.;Conn;Annu Rev Med,1994

2. Feb Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines.;Kaiser;Endocr Rev,1997

3. Characterization of the pituitary gonadotroph cells of hypogonadal (hpg) male mice: comparison with normal mice.;McDowell;J Endocrinol,1982

4. Advances in the molecular genetics of hypogonadotropic hypogonadism.;Achermann;J Pediatr Endocrinol Metab,2001

5. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function.;Bedecarrats;Mol Cell Endocrinol,2003

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