Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability

Author:

Wang Zhican1,Wong Timothy1,Hashizume Takanori2,Dickmann Leslie Z.3,Scian Michele4,Koszewski Nicholas J.5,Goff Jesse P.5,Horst Ronald L.6,Chaudhry Amarjit S.7,Schuetz Erin G.7,Thummel Kenneth E.1

Affiliation:

1. Departments of Pharmaceutics (Z.W., T.W., K.E.T.), University of Washington, Seattle, Washington 98195–7610;

2. Departments of Faculty of Pharmacy (T.H.), Osaka Ohtani University, Tondabayashi, Osaka 584-8540, Japan;

3. Department of Pharmacokinetics and Drug Metabolism (L.Z.D.), Amgen, Seattle, Washington 98119;

4. Departments of Medicinal Chemistry (M.S.), University of Washington, Seattle, Washington 98195–7610;

5. Department of Biomedical Sciences (N.J.K., J.P.G.), College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011;

6. Heartland Assays, LLC (R.L.H.), Ames, Iowa 50010;

7. Department of Pharmaceutical Sciences (A.S.C., E.G.S.), St Jude Children's Research Hospital, Memphis, Tennessee 38105

Publisher

The Endocrine Society

Subject

Endocrinology

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