Shortened Estrous Cycle Length, Increased FSH Levels, FSH Variance, Oocyte Spindle Aberrations, and Early Declining Fertility in Aging Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice: Concomitant Characteristics of Human Midlife Female Reproductive Aging

Author:

Bernstein Lori R.1234,Mackenzie Amelia C.L.2,Kraemer Duane C.5,Morley John E.6,Farr Susan67,Chaffin Charles L.8,Merchenthaler István2

Affiliation:

1. Departments of Pregmama, LLC (L.R.B.), Gaithersburg, Maryland 20886;

2. Departments of Epidemiology and Public Health (L.R.B., A.C.L.M., I.M.) University of Maryland School of Medicine, Baltimore, Maryland 21201;

3. Department of Gynecology and Obstetrics (L.R.B.), Johns Hopkins University School of Medicine, Baltimore, Maryland 21205;

4. Departments of Veterinary Integrative Biosciences (L.R.B.) Texas A&M College of Veterinary Medicine, College Station, Texas 77843;

5. Departments of Veterinary Physiology and Pharmacology (D.C.K.), Texas A&M College of Veterinary Medicine, College Station, Texas 77843;

6. Divisions of Geriatric Medicine and Endocrinology (J.E.M., S.F.), St. Louis University School of Medicine, St. Louis, Missouri 63103;

7. St. Louis Veterans Affairs Medical Center (S.F.), St. Louis, Missouri 63106

8. Departments of Obstetrics, Gynecology, and Reproductive Sciences (C.L.C.), University of Maryland School of Medicine, Baltimore, Maryland 21201;

Publisher

The Endocrine Society

Subject

Endocrinology

Reference80 articles.

1. Normal variation in the length of the follicular phase of the menstrual cycle: effect of chronological age;Lenton;Br J Obstet Gynaecol,1984

2. Hormonal characteristics of the human menstrual cycle throughout reproductive life;Sherman;J Clin Invest,1975

3. Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women;Klein;J Clin Endocrinol Metab,1996

4. The effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cycles;Lee;Hum Reprod,1988

5. Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing;Kuliev;Reprod Biomed Online,2011

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