Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin-Reference-Cited by-同舟云学术

Human Placental Tissue Contains A Placental Lactogen–Derived Vasoinhibin

Published:2022-02-20 Issue:4 Volume:6 Page:
ISSN:2472-1972
Container-title:Journal of the Endocrine Society
language:en
Short-container-title:

Author:

Markl-Hahn Hülya¹,Neugebauer Leon¹,Lenke Livia¹,Ecker Sarah²³,Merz Tamara³,McCook Oscar³,Khoder Noura⁴,Brucker Cosima⁴,Radermacher Peter³,Waller Christiane²,Clapp Carmen⁵^ORCID,Bertsch Thomas¹,Triebel Jakob¹^ORCID

Affiliation:

1. Institute for Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany

2. Department of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany

3. Institute of Anesthesiological Pathophysiology and Process Engineering, University of Ulm, 89019 Ulm, Germany

4. Department of Gynecology and Obstetrics, Nuremberg General Hospital & Paracelsus Medical University, 90419 Nuremberg, Germany

5. Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM–Juriquilla , 76230 Juriquilla, Querétaro, México

Abstract

Abstract Hormonal factors affecting the vascular adaptions of the uteroplacental unit in noncomplicated and complicated pregnancies are of interest. Here, 4 human placentas from women with and without preeclampsia (PE) were investigated for the presence of placental lactogen (PL)-derived, antiangiogenic vasoinhibin. Western blotting and mass spectrometry of placental tissue revealed the presence of a 9-kDa PL-derived vasoinhibin, the normal 22-kDa full-length PL, and a 28-kDa immunoreactive protein of undetermined nature. The sequence of the 9-kDa vasoinhibin includes the antiangiogenic determinant of vasoinhibin and could constitute a relevant factor in normal pregnancy and PE.

Publisher

The Endocrine Society

Subject

Endocrinology, Diabetes and Metabolism

Link

https://academic.oup.com/jes/advance-article-pdf/doi/10.1210/jendso/bvac029/42561722/bvac029.pdf

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