Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time?

Author:

Ho Ken1ORCID,Fleseriu Maria2,Kaiser Ursula3ORCID,Salvatori Roberto4ORCID,Brue Thierry5ORCID,Lopes M Beatriz6ORCID,Kunz Pamela7,Molitch Mark8ORCID,Camper Sally A9ORCID,Gadelha Mônica10ORCID,Syro Luis V11,Laws Edward3,Reincke Martin12ORCID,Nishioka Hiroshi13ORCID,Grossman Ashley14,Barkan Ariel9,Casanueva Felipe15,Wass John16,Mamelak Adam17,Katznelson Laurence18ORCID,van der Lely Aart J19ORCID,Radovick Sally20,Bidlingmaier Martin12ORCID,Boguszewski Margaret21ORCID,Bollerslev Jens22,Hoffman Andrew R18ORCID,Oyesiku Nelson23,Raverot Gerald24ORCID,Ben-Shlomo Anat17,Fowkes Rob25ORCID,Shimon Ilan26,Fukuoka Hidenori27ORCID,Pereira Alberto M28,Greenman Yona29ORCID,Heaney Anthony P30,Gurnell Mark31ORCID,Johannsson Gudmundur32ORCID,Osamura Robert Y33,Buchfelder Michael34,Zatelli Maria Chiara35ORCID,Korbonits Marta36,Chanson Philippe37ORCID,Biermasz Nienke28ORCID,Clemmons David R38,Karavitaki Niki39ORCID,Bronstein Marcello D40,Trainer Peter41,Melmed Shlomo17ORCID

Affiliation:

1. The Garvan Institute of Medical Research, Sydney, Australia

2. Oregon Health & Science University, Portland, OR, USA

3. Brigham and Women’s Hospital, Boston, MA, USA

4. The Johns Hopkins University School of Medicine, Baltimore, MD, USA

5. Aix-Marseille University, Marseille, France

6. University of Virginia School of Medicine, Charlottesville, VA, USA

7. Yale School of Medicine, New Haven, CT, USA

8. Northwestern University Feinberg School of Medicine, Chicago, IL, USA

9. University of Michigan Medical School, Ann Arbor, MI, USA

10. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

11. Hospital Pablo Tobon Uribe and Clinica Medellin—Grupo Quirónsalud, Medellin, Colombia

12. Klinikum der Universität, Ludwig-Maximilians-Universität, München, Germany

13. Toranomon Hospital, Tokyo, Japan

14. University of Oxford, Oxford, and Barts and the London School of Medicine, London, UK

15. Santiago de Compostela University, Santiago de Compostela, Spain

16. Churchill Hospital, Oxford, UK

17. Cedars-Sinai Medical Center, Los Angeles, CA, USA

18. Stanford University School of Medicine, Stanford, CA, USA

19. Erasmus University Medical Center, Rotterdam, The Netherlands

20. Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

21. Federal University of Parana, Curitiba, Brazil

22. University of Oslo, Oslo, Norway

23. Emory University School of Medicine, Atlanta, GA, USA

24. Hospices Civils de Lyon and Lyon 1 University, Lyon, France

25. Royal Veterinary College, University of London, London, UK

26. Rabin Medical Center, Beilinson Hospital, Petah-Tikva, Israel

27. Kobe University Hospital, Kobe, Japan

28. Leiden University Medical Center, Leiden, The Netherlands

29. Tel Aviv-Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

30. David Geffen School of Medicine University of California, Los Angeles, CA, USA

31. University of Cambridge & Addenbrooke’s Hospital, Cambridge, UK

32. Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

33. Nippon Koukan Hospital Kawasaki & Keio University School of Medicine, Tokyo, Japan

34. University Hospital Erlangen, Erlangen, Germany

35. University of Ferrara, Ferrara, Italy

36. Queen Mary University of London, UK

37. University Paris-Saclay & Assistance Publique Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicêtre, France

38. University of North Carolina School of Medicine, Chapel Hill, NC, USA

39. University of Birmingham, Birmingham, UK

40. University of São Paulo Medical School, São Paulo, Brazil

41. University of Manchester, Manchester, UK

Abstract

Abstract The WHO Classification of Endocrine Tumours designates pituitary neoplasms as adenomas. A proposed nomenclature change to pituitary neuroendocrine tumors (PitNETs) has been met with concern by some stakeholder groups. The Pituitary Society coordinated the Pituitary Neoplasm Nomenclature (PANOMEN) workshop to address the topic. Experts in pituitary developmental biology, pathology, neurosurgery, endocrinology, and oncology, including representatives nominated by the Endocrine Society, European Society of Endocrinology, European Neuroendocrine Association, Growth Hormone Research Society, and International Society of Pituitary Surgeons. Clinical epidemiology, disease phenotype, management, and prognosis of pituitary adenomas differ from that of most NETs. The vast majority of pituitary adenomas are benign and do not adversely impact life expectancy. A nomenclature change to PitNET does not address the main challenge of prognostic prediction, assigns an uncertain malignancy designation to benign pituitary adenomas, and may adversely affect patients. Due to pandemic restrictions, the workshop was conducted virtually, with audiovisual lectures and written précis on each topic provided to all participants. Feedback was collated and summarized by Content Chairs and discussed during a virtual writing meeting moderated by Session Chairs, which yielded an evidence-based draft document sent to all participants for review and approval. There is not yet a case for adopting the PitNET nomenclature. The PANOMEN Workshop recommends that the term adenoma be retained and that the topic be revisited as new evidence on pituitary neoplasm biology emerges.

Publisher

The Endocrine Society

Subject

Endocrinology, Diabetes and Metabolism

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