Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses

Author:

François Jean-Christophe12,Aïd Saba12,Chaker Zayna13,Lacube Philippe1,Xu Jie12,Fayad Racha13,Côté Francine4,Even Patrick5,Holzenberger Martin12

Affiliation:

1. INSERM Research Center Unité 938, 75012 Paris, France

2. Sorbonne University, 75005 Paris, France

3. Faculty of Medicine, University Paris Descartes, 75006 Paris, France

4. Institut Imagine INSERM Unité 1163/CNRS Equipe 8254, Necker Enfants Malades Hospital, 75015 Paris, France

5. AgroParisTech, INRA, Université Paris Saclay, Nutrition Physiology and Ingestive Behavior Unité 914, 75005 Paris, France

Publisher

The Endocrine Society

Subject

Endocrinology

Reference69 articles.

1. Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis;Epaud;PLoS One,2012

2. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r);Liu;Cell,1993

3. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice;Holzenberger;Nature,2003

4. The genetics of ageing;Kenyon;Nature,2010

5. Deep proteome analysis identifies age-related processes in C. elegans;Narayan;Cell Syst,2016

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