Potent Inhibition of Estrogen Sulfotransferase by Hydroxylated PCB Metabolites: A Novel Pathway Explaining the Estrogenic Activity of PCBs

Author:

Kester Monique H. A.12,Bulduk Sema2,Tibboel Dick1,Meinl Walter3,Glatt Hansruedi3,Falany Charles N.4,Coughtrie Michael W. H.5,Bergman Ake67,Safe Stephen H.8,Kuiper George G. J. M.2,Schuur A. Gerlienke6,Brouwer Abraham7,Visser Theo J.2

Affiliation:

1. Departments of Pediatric Surgery (M.H.A.K., D.T.), Erasmus University Medical School, 3015 GE Rotterdam, The Netherlands, D-14558 Potsdam-Rehbrücke, Germany

2. Departments of Internal Medicine (M.H.A.K., S.B., G.G.J.M.K., T.J.V.), D-14558 Potsdam-Rehbrücke, Germany

3. Departments of Pharmacology and Toxicology (W.M., H.G.), German Institute of Human Nutrition, D-14558 Potsdam-Rehbrücke, Germany

4. Departments of Pharmacology and Toxicology (C.N.F.), University of Alabama, Birmingham, Alabama 35294

5. Molecular and Cellular Pathology (M.W.H.C.), University of Dundee, Dundee DD1 9SY, United Kingdom

6. Food Technology and Nutritional Sciences, Toxicology Group (A.G.S., A.B.), Agricultural University Wageningen, 6700 EA Wageningen, The Netherlands

7. Environmental Chemistry (A.B.), Wallenberg Laboratory, Stockholm University, S-10691 Stockholm, Sweden

8. Veterinary Physiology and Pharmacology (S.H.S.), Texas A&M University, College Station, Texas 77843-4466

Publisher

The Endocrine Society

Subject

Endocrinology

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