Overexpression of Insulin-Like Growth Factor Binding Protein-5 Helps Accelerate Progression to Androgen-Independence in the Human Prostate LNCaP Tumor Model through Activation of Phosphatidylinositol 3′-Kinase Pathway*

Author:

Miyake Hideaki1,Nelson Colleen1,Rennie Paul S.1,Gleave Martin E.1

Affiliation:

1. The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia V6H 3Z6; and Division of Urology, University of British Columbia, Vancouver, British Columbia V5Z 3J5, Canada

Publisher

The Endocrine Society

Subject

Endocrinology

Reference44 articles.

1. Overview of phase III trials on combined androgen treatment in patients with metastatic prostate cancer.;Denis;Cancer,1993

2. Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system.;Isaacs;Cancer Res,1982

3. The timing of androgen ablation therapy and/or chemotherapy in the treatment of prostatic cancer.;Issacs;Prostate,1984

4. Target to apoptosis: a hopeful weapon for prostate cancer.;Tang;Prostate,1997

5. Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.;Taplin;N Engl J Med,1995

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