Differential Effects of Insulin-Like Growth Factor (IGF)-Binding Protein-3 and Its Proteolytic Fragments on Ligand Binding, Cell Surface Association, and IGF-I Receptor Signaling**This research was supported by US Army Grants DAMD17-991-9522 (to G.R.D.) and DAMD17-96-1-6204 and DAMD17-96-1-7204 (to Y.O.H.) and by NIH Grants R01-DK-51513 (to R.G.R.) and CA-58110 (to R.G.R.).

Author:

Devi Gayathri R.1,Yang Doo-Hyun1,Rosenfeld Ron G.1,Oh Youngman1

Affiliation:

1. Department of Pediatrics, School of Medicine, Oregon Health Sciences University, Portland, Oregon 97201-3042

Publisher

The Endocrine Society

Subject

Endocrinology

Reference48 articles.

1. Insulin-like growth factors and their binding proteins: biological actions.;Jones;Endocr Rev,1995

2. The insulin-like growth factor binding protein superfamily: new perspectives.;Rosenfeld;Pediatrics,1999

3. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells.;Oh;J Biol Chem,1993

4. Transfection of the human IGFBP-3 gene into Balb/c fibroblasts: a model for the cellular functions of IGFBPs.;Cohen;Growth Regul,1993

5. The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene.;Valentinis;Mol Endocrinol,1995

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