A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo**This work was supported by R01-DK-55748 from the NIH and the Frances Williams Preston Laboratories of the T. J. Martell Foundation. Transgenic mice were bred by the Transgenic Core/ES Cell Shared Resource of the Vanderbilt-Ingram Cancer Center (NCI Grant 2P30-CA-68485

A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo**This work was supported by R01-DK-55748 from the NIH and the Frances Williams Preston Laboratories of the T. J. Martell Foundation. Transgenic mice were bred by the Transgenic Core/ES Cell Shared Resource of the Vanderbilt-Ingram Cancer Center (NCI Grant 2P30-CA-68485–05).

Published:2000-12-01 Issue:12 Volume:141 Page:4698-4710
ISSN:0013-7227
Container-title:Endocrinology
language:en
Short-container-title:

Author:

Zhang JianFeng¹²³,Thomas Tania Z.¹³,Kasper Susan¹²³,Matusik Robert J.¹²³⁴⁵

Affiliation:

1. Departments of Urologic Surgery (J.Z., T.Z.T., S.K., R.J.M.) Nashville, Tennessee 37232

2. Cell Biology (J.Z., S.K., R.J.M.), Nashville, Tennessee 37232

3. The Vanderbilt Prostate Cancer Center (J.Z., T.Z.T., S.K., R.J.M.), Nashville, Tennessee 37232

4. Center for Reproductive Biology Research (R.J.M.), Nashville, Tennessee 37232

5. The Vanderbilt-Ingram Cancer Center (R.J.M.), Nashville, Tennessee 37232

Publisher

The Endocrine Society

Subject

Endocrinology

Link

http://academic.oup.com/endo/article-pdf/141/12/4698/10361562/endo4698.pdf

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3. A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression.;Shrahle;Proc Natl Acad Sci USA,1987

4. Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus.;Ham;Nucleic Acids Res,1988

5. Characterization and cloning of rat dorsal prostate mRNAs. Androgen regulation of two closely related abundant mRNAs.;Dodd;J Biol Chem,1983

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