New Insights into the Conformational Dominant Epitopes on Thyroid Peroxidase Recognized by Human Autoantibodies

Author:

Bresson Damien1,Rebuffat Sandra A.1,Nguyen Brigitte1,Banga J. Paul2,Gardas Andrzej3,Peraldi-Roux Sylvie1

Affiliation:

1. Centre National de la Recherche Scientifique Unité Mixte de Recherche 5160 (D.B., S.A.R., B.N., S.P.-R.), Centre de Pharmacologie et Biotechnologie pour la Santé, Faculté de Pharmacie, BP 14491, 34093 Montpellier Cedex 5, France

2. Division of Medicine (J.P.B.), Guy’s, King’s, and St. Thomas’ School of Medicine, King’s College London, London, United Kingdom SE1 9RT

3. Medical Centre of Postgraduate Education (A.G.), 01-813 Warsaw, Poland

Publisher

The Endocrine Society

Subject

Endocrinology

Reference25 articles.

1. Autoimmune response to the thyroid in humans: thyroid peroxidase—the common autoantigenic denominator;McLachlan;Int Rev Immunol,2000

2. Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies;Rodien;J Clin Endocrinol Metab,1996

3. Cytotoxic assay of circulating thyroid peroxidase antibodies;Wadeleux;Autoimmunity,1989

4. Complement activation by direct C4 binding to thyroperoxidase in Hashimoto’s thyroiditis;Blanchin;Endocrinology,2003

5. Evidence for antigen presentation to sensitized T cells by thyroid peroxidase (TPO)-specific B cells in mice injected with fibroblasts co-expressing TPO and MHC class II;Guo;Clin Exp Immunol,2000

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