PPARα-Dependent Induction of Liver Microsomal Esterification of Estradiol and Testosterone by a Prototypical Peroxisome Proliferator

Author:

Xu Shiyao1,Zhu Bao Ting1,Turan Valerie1,Rusyn Ivan2,Thurman Ronald2,Peters Jeffrey M.3,Gonzalez Frank J.4,Conney Allan H.1

Affiliation:

1. Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey (S.X., B.T.Z., V.T., A.H.C.), Piscataway, New Jersey 08854

2. Department of Pharmacology, University of North Carolina (I.R., R.T.), Chapel Hill, North Carolina 27599

3. Department of Veterinary Science, Center for Molecular Toxicology, Pennsylvania State University (J.M.P.), University Park, Pennsylvania 16802

4. Laboratory of Metabolism, National Cancer Institute, National Institutes of Health (F.J.G.), Bethesda, Maryland 20892

Publisher

The Endocrine Society

Subject

Endocrinology

Reference16 articles.

1. Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes.;Xu;J Pharmacol Exp Ther,2001

2. Stimulatory effect of clofibrate on the action of estradiol in the mammary gland but not in the uterus of rats.;Xu;J Pharmacol Exp Ther,2001

3. Biochemical mechanisms of induction of hepatic peroxisome proliferation.;Lock;Annu Rev Pharmacol Toxicol,1989

4. Peroxisome proliferation and nongenotoxic carcinogenesis: commentary on a symposium.;Moody;Fund Appl Toxicol,1991

5. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans.;Reddy;Crit Rev Toxicol,1983

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