Fetal Tissues Are Exposed to Biologically Relevant Free Thyroxine Concentrations during Early Phases of Development

Author:

Calvo Rosa M.1,Jauniaux Eric2,Gulbis Beatrice3,Asunción Myriam1,Gervy Christine3,Contempré Bernard4,Morreale de Escobar Gabriella1

Affiliation:

1. Unidad de Endocrinología Molecular, Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Facultad de Medicina, Universidad Autónoma de Madrid (R.M.C., M.A., G.M.d.E.), 28029 Madrid, Spain

2. Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School (E.J.), London, United Kingdom WCIE 6HX

3. Department of Clinical Chemistry, Academic Hopital Erasme (B.G., C.G.), B-1070 Brussels, Belgium

4. Institute of Interdisciplinary Research, Université Libre de Bruxelles (B.C.), B-1070 Brussels, Belgium

Publisher

The Endocrine Society

Subject

Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference62 articles.

1. Maternal hypothyroidism and fetal development;Utiger;N Engl J Med,1999

2. Ontogenesis of the nuclear 3,5,3′-triiodothyroxine receptor in the human fetal brain;Bernal;Endocrinology,1984

3. Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation;Ferreiro;J Clin Endocrinol Metab,1988

4. Thyroid hormone receptor gene expression in first trimester human fetal brain;Iskaros;J Clin Endocrinol Metab,2000

5. Is neuropsychological development related to maternal hypothyroidism, or to maternal hypothyroxinemia?;Morreale de Escobar;J Clin Endocrinol Metab,2000

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